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Professor Jane Setterfield qualified in Medicine from University College London and in Dentistry from The Royal London Hospital. She trained as a Dermatologist at St John's Institute of Dermatology and is additionally a specialist in Oral Medicine. She has undertaken research at the University of Connecticut, USA and at Guy's and St. Thomas' Hospitals.

Her current posts are Professor of Oral and Dermatological Medicine / Honorary Consultant in Dermatology, Departments of Oral Medicine & St John's Institute of Dermatology,Guy's & St Thomas NHS Foundation Trust and King's College London. She also holds an Honorary Consultant Dermatologist position at St Mary's Hospital, Imperial College Healthcare Trust, London.

Professor Setterfield practices a wide range of general dermatology. In addition she leads the oral dermatology service at Guy's Hospital. Her clinical research interests include investigation of the pathogenesis of mucocutaneous diseases with a particular emphasis on the immunobullous disorders and lichen planus. With her team she has developed and published clinical outcome measures which are vital for optimising patient care, has identified biomarkers for disease severity and identifies the optimal treatments for complex mucocutaneous diseases.

Research Interests

Investigating the pathogenetic mechanisms and clinicopathological associations of the autoimmune blistering diseases pemphigus vulgaris and mucous membrane pemphigoid as well as the more common autoimmune disease lichen planus. As a clinical academic I also lead research developing disease specific clinical outcome measures so that treatment can be optimised. I collaborate nationally and internationally in these areas and am a member of the European Task Force for autoimmune blistering diseases responsible for developing European Guidelines.

Recent Publications

Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid. Br J Dermatol. 2019 Sep 30. doi: 10.1111/bjd.18566.

The optimal oral biopsy site for diagnosis of mucous membrane pemphigoid and pemphigus vulgaris. Br J Dermatol 2019 Apr 25 doi: 10.1111/bjd.18032

Mucous membrane pemphigoid and oral blistering diseases. Clin Exp Dermatol 2019;44:732-739

WWOM VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigus and pemphigoid Oral Dis. 2019 Jun;25 Suppl 1:111-121.

WWOM VII: Immunobiologics for Salivary Gland Disease in Sjögren's Syndrome: A Systematic Review. Oral Dis. 2019 Jun;25 Suppl 1:102-110. doi: 10.1111/odi.13062

Oral ulcers as a presentation of secondary syphilis. Clin Exp Dermatol. 2018 Dec;43(8):868-875.

Oral lichen planus: aetiopathogenesis, clinical presentation and management: Lakhan M, Setterfield JF. pp 1-16. In Recent Advances in Dermatology: 1 Eds Zaheri S, Ali I. JP Medical Limited, 10 Jan 2019 ISBN 978-1-909836-58-7

Oral Vesicular and Bullous Lesions. In: Farah C., Balasubramaniam R., McCullough M. (eds) Contemporary Oral Medicine. Springer, Cham ISBN 978-3-319-28100-1

How Cross-Disciplinary Research has increased our understanding of oral mucosal diseases. In: Meurman J. (eds) Translational Oral Health Research. Springer, Cham https://doi.org/10.1007/978- 3-319.78205.8¬_2

HLA alleles in British Caucasians with mucous membrane pemphigoid. HLA alleles in British Caucasians with mucous membrane pemphigoid. Eye (Lond). 2018;32(9):1540-1541.

An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. Br J Dermatol. 2018;179:872-881

Mucous membrane pemphigoid with ocular involvement: the clinical phenotype and its relationship to direct immunofluorescence Ophthalmology. 2018 Apr;125(4):496-504.

British Association of Dermatologists' guidelines for the management of pemphigus vulgaris 2017 British Journal of Dermatology. 177, 5, p. 1170-1201

Meeting report of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich, Journal of Investigative Dermatology. 137, 6, p. 99-1203

Serum and Salivary IgG and IgA Antibodies to Dsg3 and their Relation to Disease Severity in Mucosal Pemphigus Vulgaris. Br J Dermatol. 2016 Jul;175(1):113-21

Diseases, Medical Tests and Treatments

Oral biopsies

vulval biopsies

Pilar cyst removal on scalp

Oral medicine

Lichen planus

mucocutaneous diseases