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Dr Paul Brennan
BMedSci(Hons), MBBS, FRCP
Clinical Genetics
3 reviews+ Add review
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Tue 21/05
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General Medical Council: 3677959




Dr Brennan's interest in genetics started as a medical student in the 1980s when the medical speciality of clinical genetics was in its infancy. After a research degree studying genes in the developing heart, he completed his medical training and undertook postgraduate training in adult medicine and paediatrics before specialist training in Clinical Genetics.

Dr Brennan was appointed as an NHS Consultant in Clinical Genetics in 2002 with the Northern Genetics Service based in Newcastle upon Tyne. After opening a new satellite clinical genetics department in Middlesbrough, he was appointed to the role of Clinical Director of the Northern Genetics Service in 2008, managing a clinical and laboratory team providing genetics diagnostics for the population of North East England and North Cumbria.

Dr Brennan has been Clinical Lead for Cardiac and Endocrine Genetics for the Northern Genetics Service since 2003; he was Clinical Lead for Cancer Genetics for County Durham, Tees Valley and North Yorkshire from 2002 to 2018 and is now Clinical Lead for the whole North East region.

A particular interest is the use of new technology and novel clinical pathways to improve diagnosis and management for people living with rare inherited disease. Between 2014 and 2018 he was Clinical Programme Director for the North East & North Cumbria NHS Genomic Medicine Centre, overseeing the introduction of whole genome sequencing into routine care as part of the 100,000 Genomes Project. He is engaged in a number of collaborative research projects, all of which are focused on improving diagnosis and treatment.

Dr Brennan is a keen and popular teacher and lectures to a wide range of undergraduate and postgraduate audiences in the UK and overseas. He teaches genetics for a week each year at Newcastle University's Medical School in Malaysia.




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Special Interests

Dr Brennan has a long experience of diagnosing and managing hereditary diseases in adults and young people. In general his specialist areas are:

A. Inherited cardiovascular disorders, for example:

  • Brugada syndrome
  • Long QT syndrome
  • Familial hypertrophic and dilated cardiomyopathy
  • Arrhythmogenic right ventricular cardiomyopathy
  • Sudden unexplained death
  • Familial thoracic aortic aneurysm
  • Marfan syndrome, Loeys Dietz syndrome and Meester-Loeys syndrome
  • Vascular Ehlers Danlos syndrome

B. Inherited connective tissue disorders, including

  • classical Ehlers Danlos syndrome
  • hypermobile Ehlers Danlos syndrome

C. Inherited cancer syndromes, for example:

  • Hereditary breast/ovarian cancer
  • Cowden's disease
  • Lynch syndrome
  • Familial Adenomatous Polyposis
  • Hereditary leiomyomatosis / renal cell carcinoma syndrome
  • Birt Hogg Dube syndrome
  • Li Fraumeni syndrome

C. Inherited endocrine syndromes, for example:

  • Familial paragangliomatosis
  • Von Hippel Lindau disease
  • Multiple endocrine neoplasis types 1 & 2 and familial medullary thyroid cancer)


  • Bachelor of Medical Science (Human Genetics) Newcastle University
  • Bachelor of Medicine and Bachelor of Surgery, Newcastle University

Professional Qualifications:

  • MRCP (Edinburgh)
  • FRCP (London)



I had a private consultation with Dr Paul Brennan. He was calm, considerate, and understanding. He took the time to consider the list of symptoms I gave to him prior the the consultation, to explore differential diagnoses, which I greatly appreciate. I was offered swift genetic testing and he informed me about what the results would mean, and possible treatments. Communication outside of the consultation has been great.


Dr Brennan was a lovely guy


Had a appointment for my young daughter and myself, my daughter was feeling quite nervous but that soon went as the minute we entered the room we were put at ease, the appointment was very relaxed and he listened to everything we said and he explained things clearly, he explained everything would be put in writing to me as there is a lot to take in. I would highly recommend